Toltrazuril is the result of extensive research efforts to help treat EPM (equine protozoal myeloencephalitis) & Coccidiosis. Toltrazuril can be used as both a preventative and a treatment for disease.

Findings from studies suggest this drug interferes with the division of the nucleus and the activity of mitochondria, which is responsible for respiratory metabolism in the parasite. Toltrazuril does not interfere with immune development, and usually does not require follow-up treatment, even in advanced infections (after three to five days). However, the efficacy of the drug is independent from the severity of the infection. Toltrazuril has a unique mode of action and there is no reason to be concerned with an adverse reaction or a drug-drug reaction. As Toltrazuril only has activity against protozoa, there is no effect on upset of intestinal flora and the formulation is very well tolerated. To be soluble in water, the product undiluted is very alkaline, pH 11.4.

It is recommended to repeat the treatment weekly for a couple of weeks. It is CRITICAL to clean the environment to rid it of coccidia.